At Recursion, we combine experimental biology, automation and artificial intelligence to quickly and efficiently identify treatments for human diseases. As a subject matter expert, the Senior Scientist, Computational Chemistry is responsible for working with our team of medicinal chemists in applying computational tools and techniques to accelerate our current drug discovery programs, and collaborating with other scientists in developing our AI platform leading to many additional programs over the coming years.
THE PROBLEMS YOU’LL SOLVE
You’ll work alongside chemists and data scientists to develop, onboard and implement ligand-based drug design techniques and capabilities to complement and augment the image-based phenotypic drug discovery methods already employed at Recursion.
You will work closely with the VP of Data Science and VP of Chemistry and maintain close relationships with data scientists, software engineers, and chemists. You will play a crucial role in the expansion of Recursion’s chemistry capabilities via computational sophistication as a subject matter expert and mentor for more junior computational chemists.
In this role you will:
THE EXPERIENCE YOU’LL NEED
THE PERKS YOU’LL ENJOY
WHAT WE DO
We start with various human cell types in our automated laboratory, where we perturb biology over 100k different ways each week (e.g. model a disease of interest, add a chemical compound, or some combination of those). We image the resulting cells using high throughput microscopy, resulting in about 2 million new images or greater than 20 terabytes of data each week with well over a petabyte of imaging data accumulated to date. These data are analyzed using computer vision and machine learning methods that help us measure how cell morphology changes in subtle ways in each biological context. We can answer direct questions (e.g. are there compounds that rescues a disease-specific set of morphological changes), and over time as our dataset has increased, we can ask more complex questions across biology. From the outset, our approach is agnostic to preconceived notions and dogma in biology, enabling Recursion to operate in novel target space. Our data scientists and machine learning researchers work on some of the most challenging and interesting problems in computational drug discovery and collaborate closely with our biologists and chemists, along with some of the brightest minds in the deep learning community (Yoshua Bengio is one of our advisors), who help our team develop novel ways of tackling these problems.
Recursion is an equal opportunity employer and complies with all applicable federal, state, and local fair employment practices laws. Recursion strictly prohibits and does not tolerate discrimination against applicants because of race, color, religion, creed, national origin or ancestry, ethnicity, sex, pregnancy, gender (including gender nonconformity and status as a transgender individual), age, physical or mental disability, citizenship, past, current, or prospective service in the uniformed services, or any other characteristic protected under applicable federal, state, or local law.