Recursion is expanding its portfolio at an unparalleled speed by combining image-based unbiased phenotypic screens and deep learning. Hits emerging from partner libraries or our constantly growing small molecule repurposing and diversity cassettes undergo rapid hit expansion and lead generation. Our lead optimization and preclinical development efforts are then moved towards the IND stage by small cross-functional teams.
HOW YOU’LL CONTRIBUTE
The high-level job description has only one item: do whatever is necessary to achieve our mission of decoding biology to radically improve lives. You will be the lead analytical chemist developing methods and performing the analysis of small molecules for purity/ID to support screening/hit identification and CMC. You will also contribute to our program teams by analyzing biological samples for API (ADMET) and building clinical translation through biomarker development . This newly-created position will report to our VP of Chemistry and on-board appropriate analytical instrumentation (LCMS) and build/manage a small core of analytical chemists to support all phases of small molecule drug discovery.
We're looking for chemists who want to:
WHAT YOU’LL NEED
WHAT WE DO
We start with various human cell types in our automated laboratory, where we perturb biology 100k different ways each week (e.g. model a disease of interest, add a chemical compound, or some combination of those). We image the resulting cells using high throughput microscopy, resulting in about 2 million new images or greater than 20 terabytes of data each week. These data are analyzed using computer vision and machine learning methods that help us measure how cell morphology changes in subtle ways in each biological context. We can answer direct questions (e.g. are there compounds that rescues a disease-specific set of morphological changes), and over time as our dataset has increased, we can ask more complex questions across biology. From the outset, our approach is agnostic to preconceived notions and dogma in biology, empowering Recursion to operate in unique target space. Potential treatments from this platform are then evaluated by our discovery biology team, who develop a literature-based understanding of the disease and use traditional wet-lab approaches to confirm and prioritize the hits.
Recursion is an equal opportunity employer and complies with all applicable federal, state, and local fair employment practices laws. Recursion strictly prohibits and does not tolerate discrimination against applicants because of race, color, religion, creed, national origin or ancestry, ethnicity, sex, pregnancy, gender (including gender nonconformity and status as a transgender individual), age, physical or mental disability, citizenship, past, current, or prospective service in the uniformed services, or any other characteristic protected under applicable federal, state, or local law.