At Recursion, we combine experimental biology, automation, and artificial intelligence to quickly and efficiently identify treatments for human diseases. We're hiring a Senior Scientist for our in Vivo Pharmacology group who will report to the Director of In Vivo Pharmacology to help us expand our portfolio as we guide our programs toward the clinic.  

THE PROBLEMS YOU’LL SOLVE

If you are a scientist who is motivated to have the largest impact on biological science in the shortest amount of time, you have just found your dream job! This role is ideal for someone who is creative and able to handle multiple projects simultaneously. You will identify animal models with maximum relevance to diseases of interest to Recursion, orchestrate evaluation of each of our leads in the most appropriate models, and work to advance our compounds to the clinic. Because we do not conduct any animal models on-site, you will need to find and coordinate sub-awards, sponsorships, or contracts with academic and industrial partners. You will then evaluate and interpret study results that guide essential decisions in our programs.

For this role, we're looking for scientists who are passionate about:

  • Research - Once we have identified a disease for screening, you will develop a literature-based understanding of the disease, identify the most-appropriate animal model and design studies to evaluate therapeutic agents for our disease hits.
  • Virtual Study Execution - Prior experience in model development and in vivo study execution is important. A hands-on understanding of the procedures involved is essential for designing clear and reproducible study results.
  • Collaboration - In addition to collaborating with your peers on the in vivo team, you will also work with members of the Disease Biology, Chemistry, Product, Development, Business Development, Data Science, and Engineering Teams. You'll also coordinate with all our diverse sponsors on study design, execution of study pre-work, and review of IACUC protocols.

Your goal will be to search for models of diseases that have high unmet need and be challenged to follow the science with the patient in mind.

 

THE EXPERIENCE YOU’LL NEED

  • A PhD in a biological field with 3-5 years of industry experience contributing preclinical efficacy data to project teams that enabled decisions
  • In-depth strategic experience with animal models of human disease to demonstrate therapeutic efficacy or proof of concept. Proficiency generating and validating these animal models and assessing the translational aspects of each.
  • An ability to serve as a scientific and technical advisor to project teams to develop, optimize and validate in vivo experiments and interpret experimental results
  • Experience with external in vivo study execution by partnering with a KOL or CRO while managing concurrent projects is desirable
  • Excellent interpersonal skills are also necessary for collaborating with a variety of external partners (CRO’s, academic labs, foundations, etc.)

 

THE PERKS YOU’LL ENJOY

  • Coverage of health, vision, and dental insurance premiums (in most cases 100%)
  • 401(k) with generous matching (immediate vesting)
  • Stock option grants
  • Two one-week paid company closures (summer and winter) in addition to flexible, generous vacation/sick leave
  • Commuter benefit and vehicle parking to ease your commute
  • Complimentary chef-prepared lunches and well-stocked snack bars
  • Generous paid parental leave (including adoptive)
  • Fully-paid gym membership to Metro Fitness, located just feet away from our new headquarters
  • Gleaming new 100,000 square foot headquarters complete with a 70-foot climbing wall, showers, lockers, and bike parking

 

WHAT WE DO

We start with various human cell types in our automated laboratory, where we perturb biology 100k different ways each week (e.g. model a disease of interest, add a chemical compound, or some combination of those). We image the resulting cells using high throughput microscopy, resulting in about 2 million new images or greater than 20 terabytes of data each week. These data are analyzed using computer vision and machine learning methods that help us measure how cell morphology changes in subtle ways in each biological context. We can answer direct questions (e.g. are there compounds that rescues a disease-specific set of morphological changes), and over time as our dataset has increased, we can ask more complex questions across biology. From the outset, our approach is agnostic to preconceived notions and dogma in biology, enabling Recursion to operate in novel target space. Potential treatments from this platform are then evaluated by our discovery biology team, who develop a literature-based understanding of the disease and use traditional wet-lab approaches to confirm and prioritize the hits.

 

Recursion is an equal opportunity employer and complies with all applicable federal, state, and local fair employment practices laws. Recursion strictly prohibits and does not tolerate discrimination against applicants because of race, color, religion, creed, national origin or ancestry, ethnicity, sex, pregnancy, gender (including gender nonconformity and status as a transgender individual), age, physical or mental disability, citizenship, past, current, or prospective service in the uniformed services, or any other characteristic protected under applicable federal, state, or local law.

 

Application

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