At Recursion, we combine experimental biology, automation and artificial intelligence to quickly and efficiently identify treatments for human diseases. Each week we knit together big data, biology, and bleeding-edge robotics to capture hundreds of thousands of observations. Using genetic manipulation, we create disease models in relevant human cell types, then use high throughput imaging coupled with automated image analysis to identify compounds that reverse cellular disease phenotypes. At Recursion, we are focused on conducting scalable biology, and leveraging automation to extract maximum value from every minute we spend in the laboratory. This is where you come in...
HOW YOU’LL CONTRIBUTE
The high-level job description has only one item: do whatever is necessary to help us progress in identifying treatments for diseases. Your work as part of our High Throughput Screening (HTS) team will significantly increase the speed of our drug discovery platform and will help us achieve our mission of decoding biology to radically improve lives.
As an HTS Technician, you’ll play a critical role in identifying drug candidates by executing hundreds of high-content screens per year. On a daily basis, you will draw upon basic molecular biology techniques and interact with computer-controlled automated laboratory instrumentation to conduct experiments in 384- and 1536-well plates. You can expect to work on multiple projects at the same time, in a fast-paced and exciting environment.
In this role you will have the opportunity to:
WHAT YOU’LL NEED
THE PERKS YOU’LL ENJOY
WHAT WE DO
At Recursion, we start with various human cell types in our automated laboratory, where we perturb biology 100k different ways each week (e.g. model a disease of interest, add a chemical compound, or some combination of those). We image these cells using high throughput microscopy, resulting in about 2 million new images, or greater than 20 terabytes of data, each week. These data are analyzed using computer vision and machine learning methods that help us measure how cell morphology changes in subtle ways in each biological context. We can answer direct questions (e.g. are there compounds that rescue a disease-specific set of morphological changes), and over time as our dataset has increased, we can ask more complex questions across biology. From the outset, our approach is agnostic to preconceived notions and dogma in biology, enabling Recursion to operate in novel target space. Potential treatments from this platform are then evaluated by our discovery biology team, who develop a literature-based understanding of the disease and use traditional wet-lab approaches to confirm and prioritize the hits.
Recursion is an equal opportunity employer and complies with all applicable federal, state, and local fair employment practices laws. Recursion strictly prohibits and does not tolerate discrimination against applicants because of race, color, religion, creed, national origin or ancestry, ethnicity, sex, pregnancy, gender (including gender nonconformity and status as a transgender individual), age, physical or mental disability, citizenship, past, current, or prospective service in the uniformed services, or any other characteristic protected under applicable federal, state, or local law.