At Recursion, we combine experimental biology, automation and artificial intelligence to quickly and efficiently identify treatments for human diseases. Recursion is expanding its portfolio at an unparalleled speed by combining image-based unbiased phenotypic screens and deep learning. Hits emerging from partner libraries or our constantly growing small molecule repurposing and diversity cassettes undergo rapid hit expansion and lead generation, generated from our highly validated and automated screening platform. Our lead optimization and preclinical development efforts are then efficiently driven towards the IND stage by small and agile cross-functional teams. The Manager of Compound Management will partner with compound management scientists and lead all aspects of mass compound acquisition, storage and distribution in support of drug discovery at Recursion. They will be responsible for integrating and maintaining a new state of the art compound storage/handling system and ensure strict quality standards and controls are in place as we expand capabilities into the future.
THE PROBLEMS YOU’LL SOLVE
The high-level job description has only one item: do whatever is necessary to achieve our mission of decoding biology to radically improve lives. In this role, you will act as the manager of Recursion’s compound collection maintaining inventory and supporting HTS and follow up activities on multiple programs. You will also contribute to our compound acquisition strategy and expansion of our small molecule libraries. This newly-created position will report to our VP of Chemistry and play a critical role in managing all aspects of compound management at Recursion.
We are looking for individuals who are:
THE EXPERIENCE YOU WILL NEED
THE PERKS YOU’LL ENJOY
WHAT WE DO
We start with various human cell types in our automated laboratory, where we perturb biology 100k different ways each week (e.g. model a disease of interest, add a chemical compound, or some combination of those). We image the resulting cells using high throughput microscopy, resulting in about 2 million new images or greater than 20 terabytes of data each week. These data are analyzed using computer vision and machine learning methods that help us measure how cell morphology changes in subtle ways in each biological context. We can answer direct questions (e.g. are there compounds that rescues a disease-specific set of morphological changes), and over time as our dataset has increased, we can ask more complex questions across biology. From the outset, our approach is agnostic to preconceived notions and dogma in biology, enabling Recursion to operate in novel target space. Potential treatments from this platform are then evaluated by our discovery biology team, who develop a literature-based understanding of the disease and use traditional wet-lab approaches to confirm and prioritize the hits.
Recursion is an equal opportunity employer and complies with all applicable federal, state, and local fair employment practices laws. Recursion strictly prohibits and does not tolerate discrimination against applicants because of race, color, religion, creed, national origin or ancestry, ethnicity, sex, pregnancy, gender (including gender nonconformity and status as a transgender individual), age, physical or mental disability, citizenship, past, current, or prospective service in the uniformed services, or any other characteristic protected under applicable federal, state, or local law.