At Recursion, we combine experimental biology, automation, and artificial intelligence to quickly and efficiently identify treatments for human diseases. As a Principal Scientist in our Medicinal Chemistry Group, you’ll act as lead chemist on multiple programs supporting the selection of screening libraries, hit assessments, and lead optimization efforts. You will also seek out new ways to streamline the traditional medicinal chemistry discovery process by partnering with data scientists to develop predictive models to reduce the number of molecules required to deliver clinical candidates.
THE PROBLEMS YOU’LL SOLVE
You will also contribute to our medicinal chemistry strategy and expansion of our small molecule libraries. In this newly-created position, you will play a critical role in driving external medicinal chemistry efforts to support discovery. You’ll report to the VP, Chemistry and will work with cross functional groups to contribute to project teams and deliver molecules to the clinic.
In this role, you will:
WHAT YOU’LL NEED
THE PERKS YOU’LL ENJOY
WHAT WE DO
We start with various human cell types in our automated laboratory, where we perturb biology 100k different ways each week (e.g. model a disease of interest, add a chemical compound, or some combination of those). We image the resulting cells using high throughput microscopy, resulting in about 2 million new images or greater than 20 terabytes of data each week. These data are analyzed using computer vision and machine learning methods that help us measure how cell morphology changes in subtle ways in each biological context. We can answer direct questions (e.g. are there compounds that rescues a disease-specific set of morphological changes), and over time as our dataset has increased, we can ask more complex questions across biology. From the outset, our approach is agnostic to preconceived notions and dogma in biology, enabling Recursion to operate in novel target space. Potential treatments from this platform are then evaluated by our discovery biology team, who develop a literature-based understanding of the disease and use traditional wet-lab approaches to confirm and prioritize the hits.
Recursion is an equal opportunity employer and complies with all applicable federal, state, and local fair employment practices laws. Recursion strictly prohibits and does not tolerate discrimination against applicants because of race, color, religion, creed, national origin or ancestry, ethnicity, sex, pregnancy, gender (including gender nonconformity and status as a transgender individual), age, physical or mental disability, citizenship, past, current, or prospective service in the uniformed services, or any other characteristic protected under applicable federal, state, or local law.